ResearchChemical 5IAI

5-IAI From Wikipedia, the free encyclopedia Jump to: navigation, search 5-IAI Systematic (IUPAC) name 5-iodo-2,3-dihydro-1H-inden-2-amine Identifiers CAS number 132367-76-1 ATC code None PubChem CID 131506 ChemSpider 116224 Y Chemical data Formula C9H10IN  Mol. mass 259.087 g/mol SMILES eMolecules & PubChem InChI[show]

• InChI=1S/C9H10IN/c10-8-2-1-6-4-9(11)5-7(6)3-8/h1-3,9H,4-5,11H2 Y
  Key: BIHPYCDDPGNWQO-UHFFFAOYSA-N Y

Therapeutic considerations Pregnancy cat.  ? Legal status Uncontrolled Routes Oral, Insufflated, Rectal  Y(what is this?)  (verify)
5-Iodo-2-aminoindane (5-IAI) is a drug which acts as a releasing agent of serotonin, norepinephrine, and dopamine.[1] It was developed in the 1990s by a team led by David E. Nichols at Purdue University.[2] 5-IAI fully substitutes for MDMA in rodents and is a putative entactogen in humans.[2] Unlike related aminoindane derivatives like MDAI and MMAI, 5-IAI causes some serotonergic neurotoxicity in rats, but is substantially less toxic than the its corresponding amphetamine homologue pIA, with the damage observed barely reaching statistical significance.[1]

[edit] See also

• 2-Aminoindane (2-AI)
• para-Iodoamphetamine (pIA)
• 6-Chloro-2-aminotetralin (6-CAT)

[edit] References

1. ^ a b Johnson MP, Conarty PF, Nichols DE (July 1991). "[3H]monoamine releasing and uptake inhibition properties of 3,4-methylenedioxymethamphetamine and p-chloroamphetamine analogues". European Journal of Pharmacology 200 (1): 9–16. PMID 1685125. 
2. ^ a b Nichols DE, Johnson MP, Oberlender R (January 1991). "5-Iodo-2-aminoindan, a nonneurotoxic analogue of p-iodoamphetamine". Pharmacology, Biochemistry, and Behavior 38 (1): 135–9. PMID 1826785. http://linkinghub.elsevier.com/retrieve/pii/0091-3057(91)90601-W.